Publications

A selection of recent BSRC members’ publications are listed below.

An active matter model captures spatial dynamics of actomyosin oscillations in larval epithelial cells during Drosophila morphogenesis
Mackay, E., Bebbington, A., Januschke, J., Kursawe, J., Bischoff, M. & Sknepnek, R., 20 Jan 2026, In: Proceedings of the National Academy of Sciences of the United States of America. 123, 3, p. 1-12 12 p., e2503955123.
Research output: Contribution to journalArticlepeer-review

A pragmatic trial with an optimized dose of rifampicin and moxifloxacin for the treatment of drug-susceptible pulmonary tuberculosis: a study protocol for open-label, randomized phase III trial (OptiRiMoxTB)
Mlyuka, H. J., Liyoyo, A., Nyaulingo, B., Mpolya, E., Kaswaga, O. L., Semvua, H., Lwambura, S., McHugh, T. D., Wildner, L., Sabiiti, W., Adegbite, B. R., Nliwasa, M., Khosa, C., Mbelele, P., Mbeya, B., Jeremiah, K., Boeree, M. J., Gillespie, S. H., Sloan, D. J. & Mpagama, S. G. & 1 others, SimpliciTB Consortium, 25 Feb 2026, In: Trials. 27, p. 1-14 14 p., 182.
Research output: Contribution to journalArticlepeer-review

Crystallographic and EPR-based characterisation of Cu2+-binding to serum albumin: ATCUN coordination and additional sites
Gucwa, M., Handing, K. B., Bijak, V., Ackermann, K., Chakraborty, A., Pautarak, A., Redpath, T., Lin, B., Sławek, J., Blindauer, C. A., Stewart, A. J., Bode, B. E. & Minor, W., 12 Mar 2026, (E-pub ahead of print) In: Inorganic Chemistry Frontiers .
Research output: Contribution to journalArticlepeer-review

Draft genome sequence of a non-tuberculous Mycobacterium strain isolated from a clinical urine sample
Rivas Ramos, J. E., Johnston, P. R., Hammond, R. J. H., Holden, M. T. G., Sloan, D. J. & Haag, A. F., 28 Jan 2026, In: Access Microbiology. 8, 1, p. 1-4 4 p., 001110.v3.
Research output: Contribution to journalArticlepeer-review

Harnessing the orientation of columnar discotic liquid crystals for narrowband blue emission with enhanced out-coupling efficiency toward improvement of SP-OLEDs performance
De, J., Gupta, A. K., Litvinas, D., Tenopala-Carmona, F., Lehmann, M., Gather, M. C. & Zysman-Colman, E., 7 Feb 2026, (E-pub ahead of print) In: Advanced Functional Materials. Early View, 14 p., e28081.
Research output: Contribution to journalArticlepeer-review

High-power pulsed electrochemiluminescence for optogenetic manipulation of Drosophila larval behaviour
Moon, C.-K., König, M., Sircar, R., Butscher, J. F., Alle, R., Meerholz, K., Pulver, S. R. & Gather, M. C., 5 Feb 2026, In: Light: Science & Applications. 15, 11 p., 104.
Research output: Contribution to journalArticlepeer-review

Knockout of the intracellular calcium conducting ion channel Mitsugumin 23 (MG23) protects against pressure overload induced left ventricular hypertrophy and cardiac dysfunction
Dorward, A. M., Robertson, G. B., Sneddon, C., Edel, R. C., O'Rourke, C. L., Um, I. H., Harrison, D. J., Nishi, M., Takeshima, H., Murdoch, C. E. & Pitt, S. J., 31 Jan 2026, In: FASEB Journal. 40, 2, p. 1-16 16 p., e71440.
Research output: Contribution to journalArticlepeer-review

Should I stay or should I go – does protein localisation to plasmodesmata depend on targeting signals?
Barr, Z. K. & Tilsner, J., 27 Jan 2026, In: Journal of Experimental Botany. 77, 3, p. 692–696 5 p., eraf278.
Research output: Contribution to journalReview articlepeer-review

Structure and mechanism of the broad spectrum CRISPR-associated ring nuclease Crn4
Chi, H., Hoikkala, V., McMahon, S., Graham, S., Gloster, T. & White, M., 23 Jan 2026, In: Nature Communications. 17, p. 1-10 10 p., 889.
Research output: Contribution to journalArticlepeer-review

Students as carbon accountants: calculating carbon costs of a PhD in neuroscience
Smith, W. V., Bebbington, A., Sircar, R., Gather, M. & Pulver, S., 1 Feb 2026, In: Genetics. 232, 2, iyaf268.
Research output: Contribution to journalArticlepeer-review

Swapped and non-swapped TRAAK states co-exist in membranes at a ratio influenced by temperature
Ma, Y., Ackermann, K., Waheed, Q., Postis, V., Smith, T. K., Bode, B. & Pliotas, C., 5 Mar 2026, (E-pub ahead of print) In: Nature Communications.
Research output: Contribution to journalArticlepeer-review

The catalytic enantioselective [1,2]-Wittig rearrangement cascade of allylic ethers
Kang, T., O'Yang, J., Kasten, K., Allsop, S. S., Lewis-Atwell, T., Farrar, E. H. E., Juhl, M., Cordes, D. B., McKay, A. P., Grayson, M. N. & Smith, A. D., 6 Jan 2026, (E-pub ahead of print) In: Nature Chemistry. AOP, 11 p.
Research output: Contribution to journalArticlepeer-review

Toward an improved understanding of dyslexia: reflections on a new consensus definition and its implications
Morsanyi, K., Paracchini, S., Krishnan, S., Manning, C., Milne, J., Van Herwegen, J. & Luciano, M., Feb 2026, In: Dyslexia. 32, 1, p. 1-9 9 p., e70022.
Research output: Contribution to journalComment/debatepeer-review

Abnormal plasma/serum magnesium, copper and zinc concentrations associate with the future development of cardiovascular diseases
Lin, B., Alexander, R., Fritzen, R., Mills, S., Stewart, A. J. & McCowan, C., 25 Apr 2025, In: Nutrients. 17, 9, p. 1-14 14 p., 1447.
Research output: Contribution to journalArticlepeer-review

Analysis of <i>TMEM109</i> rare genetic variation underlying cardiovascular diseases and traits among 500000 individuals in the UK Biobank
Guo, X., Paracchini, S. & Pitt, S., Nov 2025, In: European Journal of Human Genetics. 33, p. 1046-1047 2 p.
Research output: Contribution to journalAbstractpeer-review

An updated evolutionary classification of CRISPR–Cas systems including rare variants
Makarova, K. S., Shmakov, S. A., Wolf, Y. I., Mutz, P., Altae-Tran, H., Beisel, C. L., Brouns, S. J. J., Charpentier, E., Cheng, D., Doudna, J., Haft, D. H., Horvath, P., Moineau, S., Mojica, F. J. M., Pausch, P., Pinilla-Redondo, R., Shah, S. A., Siksnys, V., Terns, M. P. & Tordoff, J. & 9 others, Venclovas, Č., White, M. F., Yakunin, A. F., Zhang, F., Garrett, R. A., Backofen, R., van der Oost, J., Barrangou, R. & Koonin, E. V., 6 Nov 2025, In: Nature Microbiology. p. 1-30 30 p.
Research output: Contribution to journalArticlepeer-review

A programmatic assessment of dolutegravir adverse events and discontinuations in Uganda
Laker Odongpiny, E. A., Nicol, M., Katana, E., Owori, J., Buzibye, A., Sedan, K., Kesby, M., Holden, M., Owarwo, N., Meya, D., Castelnuovo, B., Sloan, D. J. & Sekaggya, C., 24 Jan 2025, (E-pub ahead of print) In: HIV Medicine. Early View, 14 p.
Research output: Contribution to journalArticlepeer-review

A2A adenosine receptor agonists with last-step enzymatic 18F-labelling potential (fluorinase) for positron emission tomography (PET)
Charalambous, N., Schleidt, C., Liu, R., Heitman, L. H., Dall'Angelo, S., O'Hagan, D. & Lowe, P. T., 26 Dec 2025, (E-pub ahead of print) In: European Journal of Organic Chemistry. Early View, 8 p., e202501125.
Research output: Contribution to journalArticlepeer-review

A viral SAVED protein with ring nuclease activity degrades the CRISPR second messenger cA4
Orzechowski, M. G., Hoikkala, V., Chi, H., McMahon, S., Gloster, T. & White, M., Nov 2025, In: Biochemical Journal. 482, 22, p. 1-13 13 p., BCJ20253271.
Research output: Contribution to journalArticlepeer-review

A widely-occurring family of pore-forming effectors broadens the impact of the Serratia Type VI secretion system
Reglinski, M., Hurst, Q. W., Williams, D. J., Gierlinski, M., Tegin Şahin, A., Mathers, K., Ostrowski, A., Bergkessel, M., Zachariae, U., Pitt, S. J. & Coulthurst, S. J., Dec 2025, In: EMBO Journal. 44, 23, p. 6892–6918 27 p.
Research output: Contribution to journalArticlepeer-review

Bacteria use a decoy defence molecule to set a trap for viruses
White, M. F., 1 Oct 2025, In: Nature. p. 1-2 2 p.
Research output: Contribution to journalComment/debatepeer-review

Bioactivity profiles of progressively ring-fluorinated cyclohexyl motifs in the WKYMVm peptide as formylpeptide FPR2 agonists and in keto-piperazines as antitrypanosome agents
He, M., Thomson, C. M., Thompson, D., Kuodis, V., Smith, T. K., Dall'Angelo, S. & O'Hagan, D., 3 Oct 2025, (E-pub ahead of print) In: ChemBioChem. Early View, 8 p., 2500384.
Research output: Contribution to journalArticlepeer-review

Broad substrate scope C-C oxidation in cyclodipeptides catalysed by a flavin-dependent filament
Sutherland, E., Harding, C. J., du Monceau de Bergendal, T., Florence, G. J., Ackermann, K., Bode, B. E., Synowsky, S., Sundaramoorthy, R. & Melo Czekster, C., 24 Jan 2025, In: Nature Communications. 16, 14 p., 995.
Research output: Contribution to journalArticlepeer-review

Building a cell-factory in Crithidia fasciculata: a bio-sustainable system to produce high-value polyunsaturated fatty acids
Cerone, M., Major, L. L. & Smith, T. K., 23 Jun 2025, In: Microbial Cell Factories. 24, p. 1-16 16 p., 142.
Research output: Contribution to journalArticlepeer-review

Cardiac safety of bedaquiline, delamanid and moxifloxacin co-administered with or without varying doses of sutezolid or delpazolid for the treatment of drug-susceptible TB
Koele, S. E., Stoycheva, K., Mtweve, C., Manyama, C., Mpagama, S., Mhimbira, F., Wallis, R., Ntinginya, N. E., Liyoyo, A., Huglin, B., Minja, L. T., Wagnerberger, L., Zumba, T., Noreña, I., Peter, D. D., Beattie, T., Makkan, H., Sloan, D. J., Te Brake, L. & Aarnoutse, R. E. & 9 others, McHugh, T. D., Wildner, L., Schildkraut, J., Aldana, B. H., Phillips, P. P. J., Hoelscher, M., Svensson, E. M., Heinrich, N. & PanACEA Consortium, Aug 2025, In: Journal of Antimicrobial Chemotherapy. 80, 8, p. 2305-2313 9 p.
Research output: Contribution to journalArticlepeer-review

Cas10 based 7SL-sRNA diagnostic for the detection of active trypanosomiasis
Gruschow, S., Steketee, P. C., Paxton, E., Matthews, K. R., Morrison, L. J., White, M. F. & Grey, F., 17 Mar 2025, In: PLoS Neglected Tropical Diseases. 19, 3, p. 1-17 17 p., e0012937.
Research output: Contribution to journalArticlepeer-review

Cas10 based 7SL-sRNA diagnostic for the detection of active trypanosomosis
Grüschow, S., Steketee, P. C., Paxton, E., Matthews, K. R., Morrison, L. J., White, M. F. & Grey, F., 17 Mar 2025, In: PLoS Neglected Tropical Diseases. 19, 3, p. 1-17 17 p., e0012937.
Research output: Contribution to journalArticlepeer-review

Characterising PMP22 proximal partners in a Schwann cell model of Charcot-Marie-Tooth disease type1A
Holt, I., Emery, N., Gates, M. A., Brown, S. J., Shirran, S. & Fuller, H. R., 5 Nov 2025, In: Biology. 14, 11, p. 1-32 32 p., 1552.
Research output: Contribution to journalArticlepeer-review

Chiral molecular 4f qubits by post functionalization
Hansen, S. H., Buch, C. D., Bode, B. E. & Piligkos, S., 21 Dec 2025, In: Inorganic Chemistry Frontiers . 12, 24, p. 8000-8007 8 p.
Research output: Contribution to journalArticlepeer-review

Clinical standards for antimicrobial stewardship in TB care
Brehm, T. T., Akkerman, O. W., Sotgiu, G., Tiberi, S., Chang, K.-C., Dheda, K., Duarte, R., Vambe, D., Udwadia, Z. F., Chesov, D., Mendelson, M., Iswari Saktiawati, A. M., van Ingen, J., Eyuboglu, F. O., Tängdén, T., Quang Vo, L. N., Riccardi, N., Moschos, C., Friedland, J. S. & Lillebaek, T. & 40 others, Chandy, S. J., Caminero, J. A., Thwaites, G., Gandra, S., Thursky, K., George, I. A., Konstantynovska, O., Fatima, R., Yim, J.-J., Kwak, N., Olaru, I. D., Gillespie, S. H., Kherabi, Y., Perl, S. H., Grønningen, E., Rodrigues, C., Bjerrum, S., Bange, F., Cox, V., Cirillo, D. M., Saluzzo, F., Hara, G. L., Wagner, D., Ismail, N., Sloan, D. J., Eshun-Wilsonova, I., Zeng, M., Cantero, C., Vasankari, T., Mandalakas, A., Kay, A., Ness, T., Torrico, M. M., Günther, G., Kuksa, L., Guglielmetti, L., García-Basteiro, A. L., Marks, G. B., Pulcini, C. & Lange, C., 10 Dec 2025, In: IJTLD open. 2, 12, p. 716-726 11 p.
Research output: Contribution to journalArticlepeer-review

CNV landscape of Hong Kong Chinese population and detection of rare CNV aggregation in twin pairs with specific learning disorders
Chung, C. Y., Jiang, W., Chau, M. H. K., Pan, D. J., Zheng, M., Paracchini, S., Dong, Z., McBride, C. A., Maurer, U. & Choy, R. K. W., Nov 2025, In: European Journal of Human Genetics. 33, p. 1091-1091 1 p.
Research output: Contribution to journalAbstractpeer-review

Competitive behaviors in Serratia marcescens are coordinately regulated by a lifestyle switch frequently inactivated in the clinical environment
Williams, D. J., Hawkins, A., Hernandez, R. E., Mariano, G., Mathers, K., Buchanan, G., Stonier, B. J., Inkster, T., Leanord, A., Chalmers, J. D., Thomson, N. R., Holden, M. T. G. & Coulthurst, S. J., 12 Feb 2025, In: Cell Host & Microbe. 33, 2, p. 252-266.E5 20 p.
Research output: Contribution to journalArticlepeer-review

Conference report: The second bacterial genome sequencing Pan-European Network conference
Wei, K. C., Purushothaman, S., Azzato, F., Baker, K. S., Birkeland, K. W., Brunet, S., Campos, J., Connor, T. R., Giske, C. G., Greub, G., Hallbäck, E. T., Harmsen, D., Hodcroft, E. B., Holden, M. T. G., Jacob, J., Kahles, A., Lagos, A. C., Lipworth, S., Loo, E. & Miotto, P. & 15 others, Neher, R. A., Neves, A., Ready, D., Roloff, T., Rooney, A., Rousseau, E., Schrenzel, J., Sundqvist, M., Viegas, S., Wegner, F., Aamot, H. V., Niemann, S., Williamson, D. A., Mölling, P. & Egli, A., 23 Oct 2025, In: Microbes and Infection. 27, 7, p. 1-8 8 p., 105557.
Research output: Contribution to journalArticlepeer-review

CRB2 depletion induces YAP signaling and disrupts mechanosensing in podocytes
Sun, Y., Kronenberg, N. M., Sethi, S. K., Dash, S. N., Kovalik, M. E., Sempowski, B., Strickland, S., Raina, R., Sperati, C. J., Tian, X., Ishibe, S., Hall, G. & Gather, M. C., 1 Apr 2025, In: American Journal of Physiology - Renal Physiology. 328, 4, p. F578-F595 18 p.
Research output: Contribution to journalArticlepeer-review

Cryo-EM structure of the conjugation H-pilus reveals the cyclic nature of the TrhA pilin
Ishimoto, N., Wong, J. L. C., He, S., Shirran, S., Wright-Paramio, O., Seddon, C., Singh, N., Balsalobre, C., Sonani, R. R., Clements, A., Egelman, E. H., Frankel, G. & Beis, K., 22 Apr 2025, In: Proceedings of the National Academy of Sciences. 122, 16, p. 1-8 8 p., e2427228122.
Research output: Contribution to journalArticlepeer-review

Data from
The University of St Andrews Research Portal.